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Biotechnology research and education program (brep)

brep > Bioprocess scale-up Facility


Founded in 1985, The Bioprocess Scale-Up Facility (BSF) is the Biotechnology Research and Education Program's modern bioprocessing laboratory dedicated to the development and scale-up of fermentation biotechnology products and processes, specifically bacteria and yeast. With over 1500 fermentations conducted since 1998, the BSF has accelerated the R&D of local biotechnology leaders such as MedImmune and Martek, and provided supplemental support the research of various US government agencies including  Edgewood Chemical Biological Center, USDA and the NIH.

Our Capabilities include:

  • Fermentation
  • Separation
  • Purification
  • Product Analysis
  • Challenging problems such as biopolymers, turbulence and multiphase fluid dynamics, biosensors, process analysis and control, and both metabolic and biochemical engineering.

Advantages of the BSF:

The BSF enables small manufacturing companies to offer extended capabilities to major pharmaceutical (Big Pharma) companies out-of-state

Production processes are directly transferable to partners operating under cGMPs (required for FDA-approved clinical trials), such as Paragon Bioservices and Advanced Bioscience Labs

100% of undergraduates employed by the BSF go on to work in the  Biotech industry following graduation

The BSF enables small manufacturing companies to offer extended capabilities to major pharmaceutical (Big Pharma) companies out-of-state

Companies and Labs Utilizing the BSF

3-Dimension Pharmaceuticals
Action Products, Inc. (Hagerstown)
Advanced BioScience Laboratories, Inc. (Kensington)
Advanced BioNutrition (Columbia)
Athena Environmental Sciences Inc. (Baltimore)
Atto Instruments, Inc. (Rockville)
Brassica, Inc. (Baltimore)
Becton Dickinson Microbiology Systems (Cockeysville)
Bioscience Contract Production Corporation (Baltimore)
Biosys Inc. (Columbia)Biospherics, Inc. (Beltsville)
Biotechnology Research Labs, Inc. (Rockville)
Cambrex (Walkersville)
Cambrex (Baltimore)
CarboMedCell Trends, Inc. (Middletown)
Chesapeake Biologicals (Baltimore)
Chesapeake PERL (Savage)
Chitin Works, Inc. (Cambridge)
Claragen, Inc. (College Park)
Crop Genetics International, Inc. (Columbia)
Digene Corporation (Gaithersburg)
Dynagen, Inc.EntreMed, Inc. (Rockville)
Environmental Elements, Inc. (Baltimore)
Enzion, Inc.Gene Logic, Inc. (Rockville)
Human Genome Sciences, Inc. (Rockville)
ID BiomedicalIgen, Inc. (Rockville)
Igene, Inc. (Columbia)
Instrument Research Company, Inc. (Columbia)
Innovative Biosensors (College Park)
IOMAI (Gaithersburg)

ISP Mineral Products, Inc. (Hagerstown)
Kemp Biotechnologies, Inc. (Frederick)
LifeTechnologies/BRL/Gibco, Inc. (Rockville)
Magenta, Inc. (Baltimore)
Martek Biosciences Corp. (Columbia)
MedImmune, Inc. (Gaithersburg)
Microbiological Associates (Rockville)
Midland Reagent Company
Molecular Oncology, Inc. (Gaithersburg)
New Earth Sciences, Inc. (Cambridge)
New York Blood Center
Oceanix (Baltimore)
Oncologix, Inc. (Rockville)
OncoImmunin, Inc. (College Park)
Oncor, Inc. (Gaithersburg)
Organon Technica
Orphan Medical
Paragon Biotech, Inc. (Baltimore)
PerImmune, Inc. (Rockville)
Procter & Gamble (Baltimore)
Proneuron Co. (Rockville)
Proteinix, Inc. (Rockville)
Prozyme, Inc.
Puresyn, Inc
SRCHEM, Inc. (Elkridge)
Ventenna Medical Systems (Gaithersburg)
Wheaton Science

National Institutes of Health 
National Institute of Standards and Technology 
Naval Research Laboratory 
US Army, EdgewoodResearch Development and Engineering Center (ERDEC)
 US Army, Walter Reed Research Institute 
United States Department of Agriculture, Beltsville, MD, Martinsburg, WV

University of Maryland
Center for Vaccine Development
Animal Science
Cell Biology and Molecular Genetics
University of Maryland Biotechnology Institute
University of Virginia
Duke Medical
Ain Shams University, Cairo
The University of Trieste
University of California, Irvine

In addition to the preceding, the BSF has provided education/ training courses to the following: CIA UniversityMedImmune, Gaithersburg, MDUniversity of Maryland Undergraduate Classes: BSCI 223, BSCI 288, ENCH 437, ENCH 482, ENCH 648, ENBE 489, ENBE 499University of Maryland Fermentation WorkshopUniversity of Maryland Purification Workshop


Kevin Knapstein
Manager, Bioprocess Scale-Up Facility
Tel: 301.314.7806 

Bioprocess Scale-Up Facility
1203 Chemical and Nuclear Engineering Building #090
University of Maryland
College Park, MD 20740

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